Dental Hypotheses_41

Platelet-rich Preparation may serve as a Powerful Tool for Therapeutic Dental Pulp Regeneration

Hai-Hua Sun, Tie-Jun Qu, Qing Yu, Fa-Ming Chen

Abstract


Introduction: Regeneration of dental pulp tissues presents one of the most challenging issues in regenerative dentistry due to their extremely poor intrinsic ability for self-healing and regrowth.

The hypothesis: We hypothesize that patient-derived platelet-rich preparation can be used in clinical endodontic regenerative procedure, serving as a powerful tool for therapeutic dental pulp regeneration.

Evaluation of the hypothesis: The cell transplantation does not always obtain the good result because of the low survival rate of transplanted cells. In addition, the use of ex vivo manipulated cell products faces many translational hurdles in treating non-vital disease. Recently, the body cells are focused as a potential source for therapeutics. Some researchers have demonstrated that endogenous stem cells may be recruited to a desired anatomic site pharmacologically. This is spurring interest in developing new generation of biomaterials that incorporate and release selected powerful extracellular influences in a near-physiological fashion, and subsequently capture endogenous stem cells and influence their fates for regeneration. The use of patient-derived products such as platelet-rich preparations that contain a multitude of endogenous growth factors and proteins is a clinically translatable biotechnology for this proposes. These simple and cost efficient procedures may have a potential impact in reducing the economic costs for standard medical treatments in regenerative endodontics.

 

Key words: Cell recruitment; Regenerative dentistry; Endogenous repair; Biomaterials; Pulp regeneration.

 

doi:10.5436/j.dehy.2011.2.00041



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