Effect of Local and Application of Amitriptyline and Imipramine on Teeth with Irreversible Pulpitis Failed Pulpal Anesthesia: A Randomized, Double-blind, Controlled Trial

Mohsen Aminsobhani; Naghmeh Meraji; Abdollah Ghorbanzadeh; Majid Ajami; Seied Ali Seiedi Hoseini; Mohammad J Kharazifard

doi:10.4103/2155-8213.195969

Official publication of the American Biodontics Society and the Center for Research and Education in Technology

ORIGINAL RESEARCH

Year : 2016 | Volume : 7 | Issue : 4 | Page : 128-132

Effect of Local and Application of Amitriptyline and Imipramine on Teeth with Irreversible Pulpitis Failed Pulpal Anesthesia: A Randomized, Double-blind, Controlled Trial

Mohsen Aminsobhani¹, Naghmeh Meraji², Abdollah Ghorbanzadeh², Majid Ajami¹, Seied Ali Seiedi Hoseini³, Mohammad J Kharazifard⁴
¹ Department of Endodontics, School of Dentistry, AJA University of Medical Sciences, Tehran; Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
² Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
³ Private Practice, Tehran, Iran
⁴ Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Naghmeh Meraji
Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran
Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/2155-8213.195969

Clinical trial registration IRCT201110317963N1

Introduction: To evaluate the analgesic effect of amitriptyline and imipramine after local application on the dentine of “hot teeth” with failed pulpal anesthesia. Materials and Methods: This study was a randomized, double-blind clinical trial that was performed on 33 consenting adult patients who were referred to us and had mandibular molars diagnosed with symptomatic irreversible pulpitis and experienced pain during access cavity preparation after receiving successful inferior alveolar nerve block with lidocaine. Either amitriptyline, imipramine or placebo was administered locally on the exposed dentine of the teeth. Pre and post-application pain levels were evaluated by McGill visual analog scale. Results: Amitriptyline significantly reduced the pain experienced by patients (P = 0.032). Imipramine also reduced the experienced pain but the pain relief was not statistically significant when compared with the placebo. Conclusion: Local administration of amitriptyline on exposed dentine can reduce the pain experienced by patients with a “hot tooth.”

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