Search Article 
Advanced search 
Official publication of the American Biodontics Society and the Center for Research and Education in Technology
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 17-22

N-acetylcysteine as a candidate therapeutic for recurrent aphthous and aphthous-like ulcers

1 Department of Restorative Dental Sciences, Alfarabi Colleges, Riyadh, Saudi Arabia
2 Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia
3 Department of Oral Medicine, Faculty of Dentistry, Damascus University, Damascus; Department of Oral Medicine, Faculty of Dentistry, Syrian Private University, Damascus, Syria
4 Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania, USA

Correspondence Address:
Saleem Abdulrab
Department of Restorative Dental Sciences, Al Farabi colleges, Riyadh
Saudi Arabia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2155-8213.202028

Rights and Permissions

Introduction: Recurrent aphthous stomatitis (RAS) is a painful ulcerative oral disease with a general population prevalence exceeding 20%. The etiology of RAS remains largely unknown, however, nutritional deficiency, autoimmunity, psychological stress, and, recently, oxidative stress have been implicated. The pain associated with RAS may be very severe and disabling, hence, treatment is centered on the control of pain and acceleration of healing. N-acetylcysteine (NAC) is a potent antioxidant with anti-inflammatory, immune-modulatory, and antimicrobial properties. It is available as a safe dietary supplement, and has been successfully used as adjuvant/treatment of inflammatory conditions including ulcerative lesions. The Hypothesis: Using NAC as a candidate for treatment and/or prevention of RAS and aphthous-like ulcers is hypothesized here. We propose to use NAC systemically or topically in the form of powder, paste, adhesive tablets, or mouthwash to treat active RAS or for prophylaxis in cases with frequent attacks. Evaluation of the Hypothesis: The current hypothesis should be tested on animal models of RAS. However, because NAC is currently approved and used for other indications, the hypothesis can also be directly evaluated in well-designed, randomized clinical trials.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded466    
    Comments [Add]    

Recommend this journal